Reiki, the subject of our research, is a complementary medicine practice within energy approaches. Discovered in Sanskrit texts by Dr. Usui in Japan in the late 19th century, it was demonstrated through studies demonstrating its effectiveness in symptoms of pain, depression, insomnia, and fatigue. Everything in the universe, including the human body, is composed of energy; any disruption in this energy can lead to illness. There are seven chakras where Reiki is applied. The main chakra centers are located along the spine. During Reiki treatments, the hands are held in each position, touching the head, neck, chest, abdominal cavity, and groin for 3-5 minutes. This period may extend to 10-20 minutes in problematic areas. The average treatment duration is 30-90 minutes. During the treatment, the patient lies down or reclines, and there is no need to remove clothing. During Reiki treatment, individuals may report a slight warming sensation under or near the therapist's hand. The only rule in Reiki practice is that the individual gives the practitioner permission to facilitate the flow of energy. The person receiving Reiki does not need to believe in Reiki during the treatment. Reiki is a universal life energy present in everyone. Reiki is generally safe, and no serious side effects have been reported. Over the last 10 years, Reiki practice has been increasing among physicians, nurses, and other healthcare professionals. This study will compare the effects of acupressure and Reiki treatments on functionality and quality of life in patients with multiple sclerosis.