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Early Detection of Selected Neuropathologies in Motor Vehicle Drivers

Status: Recruiting

Study Type: Observational

SUMMARY

This study aims to develop accessible methods for the early detection of selected neuropathologies in drivers, focusing on multiple sclerosis and Parkinson's disease. The primary objective is to identify clinical tests that correlate with outcomes from the Vienna Test System (VTS), thereby enabling early diagnosis without the need for complex neurological or neuropsychological assessments. Findings could improve the effectiveness of routine driver medical check-ups and inform future modifications to Czech traffic law to enhance road safety.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 18

Maximum Age: 85

Healthy Volunteers: f

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• Person after signing informed consent.

• After meeting the valid diagnostic criteria for the given neurological diagnosis.

• Possession of a valid driver's license and proof of active driving.

• Age limit 18 - 85 years.

Contact Information

Primary

Dalibor Zimek, M.D.

Dalibor.Zimek@fnol.cz

+420 702 048 036

Backup

Ladislav Stanke, Ph.D.

Ladislav.Stanke@fnol.cz

+420 588 443 713

Time Frame

Start Date: 2025-11-01

Estimated Completion Date: 2028-12-31

Participants

Target number of participants: 200

Treatments

Parkinson disease cohort

PD patients cohort will consist of 100 patients with parkinson disease aged between 18-85 years, with, with a balanced sex distribution to ensure representativeness and reduce gender bias. The target sample size (N = 100) has been chosen to provide adequate statistical power to detect moderate to strong correlations between clinical and paraclinical measures , we also want to distribute patients regularly across all those ages. Participants with premorbid cognitive impairment or those not clinically stable during the study period will be excluded, also participants with a Hoehn and Yahr stage greater than 4 will be excluded.

Multiple sclerosis cohort

Multiple sclerosis patient cohort will consist of 100 patients with multiple sclerosis. aged between 18-85 years, with, with a balanced sex distribution to ensure representativeness and reduce gender bias. The target sample size (N = 100) has been chosen to provide adequate statistical power to detect moderate to strong correlations between clinical and paraclinical measures , we also want to distribute patients regularly across all those ages. Participants with premorbid cognitive impairment or those not clinically stable during the study period will be excluded also an Expanded Disability Status Scale (EDSS) score above 6.5 will serve as an exclusion criterion.

Related Therapeutic Areas

Multiple Sclerosis (MS)

Movement Disorders

Parkinson's Disease

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