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Is Silodosin Effective for Treating Lower Urinary Tract Symptoms in Female Patients With Multiple Sclerosis? A Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The goal of this clinical trial is to learn if silodosin works to treat lower urinary tract symptoms (LUTS) in female patients with multiple sclerosis (MS). It will also learn about the effect of the drug on voiding parameters. The main questions it aims to answer are: Does silodosin improve lower urinary tract symptoms based on questionnaires? Does silodosin change Uroflowmetry parameters in female patients with MS? Researchers will compare silodosin to a placebo (a look-alike substance that contains no drug) to see if silodosin works to treat LUTS in female patients with MS. Participants will: Take silodosin or a placebo every day for 8 weeks Visit the clinic before initiating the medication and after 8 weeks of taking the medication for questionnaires and tests

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:

• Female patients with a diagnosis of multiple sclerosis

• Age \> 18

• Moderate to severe lower urinary tract symptoms as defined by an AUASS score \> 8

• No UTI

Locations
United States
New Jersey
Atlantic Health
RECRUITING
Morristown
Contact Information
Primary
Mariah McKevitt, MD
mariah.mckevitt@atlantichealth.org
973-971-7267
Time Frame
Start Date: 2026-04
Estimated Completion Date: 2028-04
Participants
Target number of participants: 60
Treatments
Experimental: Silodosin
Silodosin 8mg PO daily
Placebo_comparator: Placebo
Identical placebo capsule, 1 capsule PO daily
Related Therapeutic Areas
Sponsors
Leads: Atlantic Health System

This content was sourced from clinicaltrials.gov

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