North American Prodromal Synucleinopathy Consortium Stage 2
Status: Recruiting
Location: See all (9) locations...
Study Type: Observational
SUMMARY
This study will enroll participants with idiopathic REM sleep behavior disorder (RBD) and healthy controls for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• Polysomnogram-confirmed RBD by ICSD-3 criteria
• Capable of providing informed consent at time of study enrollment
• Age \> 18 years
• Ability to provide written consent
• Age \> 18 years
• Must meet age, sex, and race matching criteria per the Data Management and Statistical core recommendations for the site
• Must be willing to undergo all testing procedures, including neuroimaging and lumbar puncture.
• Normal capacity to perform complex activities of daily living independently based on informant or physician report
Locations
United States
California
University of California Los Angeles
RECRUITING
Los Angeles
Stanford University
RECRUITING
Redwood City
Georgia
Emory University
RECRUITING
Atlanta
Massachusetts
Massachusetts General Hospital
RECRUITING
Boston
Minnesota
University of Minnesota
RECRUITING
Minneapolis
Mayo Clinic Rochester
RECRUITING
Rochester
Missouri
Washington University School of Medicine
RECRUITING
St Louis
Oregon
Oregon Health Sciences University
RECRUITING
Portland
Other Locations
Canada
McGill University Health Centre Research Institute
RECRUITING
Montreal
Contact Information
Primary
Jennifer McLeland, PhD
mclelandj@wustl.edu
314-747-3819
Backup
Leah Taylor
ltaylor24@wustl.edu
314-747-7297
Time Frame
Start Date: 2022-08-12
Estimated Completion Date: 2025-05-01
Participants
Target number of participants: 500
Treatments
RBD group
Clinical observation involving annual visits to a study site for up to 5 years.
control group
Clinical observation involving annual visits to a study site for up to 5 years.
Related Therapeutic Areas
Sponsors
Collaborators: Mayo Clinic, Emory University, Stanford University, McGill University, Massachusetts General Hospital, Oregon Health and Science University, National Institute on Aging (NIA), National Institutes of Health (NIH), University of Minnesota, University of California, Los Angeles, National Institute of Neurological Disorders and Stroke (NINDS)
Leads: Washington University School of Medicine