Differential Diagnosis Between Parkinson's Disease and Multiple System Atrophy Using Digital Speech Analysis - Part 2 - Voice4PD-MSA-II
Parkinson's disease (PD) is the second most common neurodegenerative disease. Multiple system atrophy (MSA) is a relentlessly progressing rare neurodegenerative disease of unknown etiology. The differential diagnosis between the MSA-Parkinsonism (MSA-P) subtype and PD can be very challenging in early disease stages, while early diagnostic certitude is important for the patient because of the diverging prognosis. At the time being, there exists no validated objective biomarker to guide the clinician. Dysarthria is a common early symptom in both diseases and of different origin. The ambition and the originality of this project are to develop a digital voice-based tool for objective discrimination between PD and MSA-P.
⁃ Age from 30 to 80 years old
• Signed informed consent
• Affiliated to social security
• Patient with PD :
∙ Diagnosis of idiopathic Parkinson's disease (PD) according to criteria (Postuma et al., 2015)
‣ Patient PD : Hoehn\&Yahr stage between 1 and 2
‣ Patient with or without mild to moderate speech troubles: MDS-UPDRS III item 1 ≤ 2
• Patients with MSA-P :
∙ Diagnosis of Multiple Atrophy System (MSA) Parkinsonian form possible or probable according to current consensus criteria (Gilman et al., 2008)
‣ Patient MSA-P: score of part IV of the UMSARS ≤ 3 points
‣ Patient with or without mild to moderate speech troubles: UMSARS II item 2 ≤ 2
• Controls :
∙ Absence of neurologic and oto-rhino-laryngologic disease