TSPO PET in the Evaluation of Neuroinflammation in Patients with Multiple System Atrophy
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
The aim of this study was to apply PET/MR techniques targeting TSPO to explore the temporal and spatial alterations characterizing neuroinflammation in MSA patients, and to assess its value as a biomarker for diagnostic typing, disease severity, and prognosis of MSA disease.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 35
Maximum Age: 80
Healthy Volunteers: t
View:
• Age\> 35 years old, gender is not limited;
• Clinically confirmed MSA and clinically probable MSA according to the 2022 MDS MSA diagnostic criteria;
• all patients had been ruled out of polyQ disease by genetic testing;
• Voluntarily participate in this study and sign the informed consent form.
Locations
Other Locations
China
Third Xiangya Hospital of Central South University
RECRUITING
Hunan
Contact Information
Primary
He RQ 何
hrq1234562001@163.COM
0086 186 2214 8869
Time Frame
Start Date: 2024-09-14
Estimated Completion Date: 2026-03-31
Participants
Target number of participants: 90
Treatments
MSA-C group
Clinically confirmed MSA and clinically probable MSA according to the 2022 MDS MSA diagnostic criteria，and have symptoms of MSA-C type (with cerebellar ataxia as the main manifestation) mainly include progressive cerebellar ataxia and autonomic dysfunction.
MSA-P group
Clinically confirmed MSA and clinically probable MSA according to the 2022 MDS MSA diagnostic criteria，and have symptoms of MSA-P (multiple system atrophy-P type) mainly include autonomic dysfunction, Parkinson's syndrome and cerebellar ataxia.
healthy control group
The healthy person who age, gender and other basic conditions matched with the MSA cohort population，and voluntarily participate in this study and sign the informed consent.
Related Therapeutic Areas
Sponsors
Leads: Min Zhao,MD