Transfusion in Lower Risk MDS Patients: Predictors of Adequacy of Transfusion and Quality of Life Changes
Observational study to evaluate changes in quality of life (QoL) in patients diagnosed with low risk MDS who are red blood cell (abc) transfusion dependent. Changes in QoL will be correlated with patient cardiorespiratory function. Cardiac biomarkers and plasma cytokines will also be evaluated.
• They must be able to understand the study procedures, comply with them, and consent in writing prior to any specific study procedure.
• Must be able to understand the study procedures, comply with them, and give written informed consent prior to any study-specific procedure.
• Adult subjects ≥ 18 years of age with a diagnosis of myelodysplastic syndrome.
• Very low, low or intermediate IPSS-R risk category.
• Subject requires are red blood cell transfusion dependent with the following criteria: requires an average of 2 to 6 units of CH on average over an 8-week period.
• ECOG 0-3.