A 6-Month Multicenter, Open-Labelled Extension of the Clinical Trial NLS-1021 in Narcoleptic Patients With and Without Cataplexy

Who is this study for? Adults with narcolepsy
What treatments are being studied? Mazindol
Status: Completed
Location: See all (22) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

This is a multicenter, open-label extension of the clinical study NLS-1021, evaluating long-term safety, tolerability, pharmacokinetics (PK), and therapeutic response to treatment with NLS-2 in adult subjects with narcolepsy.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• The subject must complete all Study NLS-1021 study requirements and assessments up to Visit 6;

• The subject is able, in the opinion of the Investigator, to receive NLS-2 for the 24-week Treatment Phase of this study;

• Biological females of childbearing potential must agree to use a medically acceptable double-barrier method of contraception for at least 30 days prior to Day 1 and until completion of the study;

• The subject is able to comply with the open-labelled extension design schedule and other study requirements;

• The subject provides written informed consent for the open-label extension study.

Locations
United States
Alabama
Sleep Disorders Center of Alabama
Birmingham
California
Stanford Sleep Medicine Center
Redwood City
Pacific Research Network
San Diego
Florida
St. Francis Sleep Allergy and Lung Institute
Clearwater
Ivetmar Medical Group
Miami
Sleep Medicine Specialists of South Florida
Miami
The Angel Medical Research Corporation
Miami Lakes
Georgia
NeuroTrials Research
Atlanta
Treken Primary care
Atlanta
Clinical Research Institute
Stockbridge
Hawaii
Hawaii Pacific Neuroscience Clinical Research Center
Honolulu
Maryland
The Center For Sleep & Wake Disorders
Chevy Chase
Michigan
Sleep and Attention Disorders
Sterling Heights
Missouri
Neurology and Sleep Disorders Clinic
Columbia
North Carolina
Carolinas Sleep Specialists
Concord
Superior Clinical Research, LLC
Goldsboro
Advanced Respiratory and Sleep Medicine
Huntersville
Ohio
Intrepid Research
Cincinnati
Ohio Sleep Medicine Institute
Dublin
South Carolina
Bogan Sleep Consultants
Columbia
Texas
Dharma PA d/b/a Southwest Family Medicine Associates
Dallas
Sleep Therapy & Research Center
San Antonio
Time Frame
Start Date: 2021-10-26
Completion Date: 2023-01-19
Participants
Target number of participants: 52
Treatments
Experimental: NLS-2 (mazindol extended release)
NLS-2 (mazindol extended release) administered once a day.
Sponsors
Leads: NLS Pharmaceutics

This content was sourced from clinicaltrials.gov