Effect of Full-House Endoscopic Sinus Surgery With Versus Without Nasopharyngeal Lymphoid Ablation on Local Mucosal Inflammation in Chronic Rhinosinusitis With Nasal Polyps

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study is designed to evaluate whether the addition of nasopharyngeal lymphoid tissue ablation to full-house endoscopic sinus surgery (ESS) provides superior control of nasal mucosa inflammation compared to full-house ESS alone in patients with nasal polyps. Thirty-two adult participants will be randomly assigned to undergo either full-house ESS only or full-house ESS combined with nasopharyngeal lymphoid tissue ablation. The primary outcome will be assessed through changes in inflammatory cell profiles at 1, 3, and 6 months postoperatively. Secondary outcomes include inflammatory cytokine levels, symptom scores, endoscopic findings, polyp recurrence rates, and safety measures.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• Aged 18-65 years

• Diagnosed with CRSwNP according to EPOS criteria

• Blood eosinophil count \> 0.3 × 10⁹/L

Locations
Other Locations
China
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
RECRUITING
Wuhan
Contact Information
Primary
Yin Yao
Dr.yaoyin@hotmail.com
86 15071077020
Backup
Xing-Liang Wu
15131662389@163.com
86 15131662389
Time Frame
Start Date: 2025-07-01
Estimated Completion Date: 2026-08-01
Participants
Target number of participants: 32
Treatments
Experimental: Full-House Endoscopic Sinus Surgery Combined with Nasopharyngeal Lymphoid Tissue Ablation
Active_comparator: Full-House Endoscopic Sinus Surgery
Sponsors
Leads: Tongji Hospital

This content was sourced from clinicaltrials.gov