• Patients with newly histologically confirmed non-keratinizing nasopharyngeal carcinoma

• Clinical staged as T4 or N3 （according to the 8th AJCC edition）

• No evidence of distant metastasis (M0)

• Male and no pregnant female

• ECOG (Eastern Cooperative OncologyGroup) scale 0-1

• WBC ≥ 4×109 /L and PLT ≥4×109 /L and HGB ≥90 g/L

• Normal liver function test (ALT、AST ≤ 2.5×ULN, TBIL≤ 2.0×ULN)

• Normal renal function test ( creatinine clearance ≥60 ml/min)