Individualized Elective Neck Irradiation Based on the Lymph Node Metastasis Pattern in NPC Patients
Status: Recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
To evaluate whether individualized elective neck irradiation for nasopharyngeal carcinoma based on the vertebral level of metastatic lymph nodes can reduce the incidence of radiation-related adverse effects and improve patients' quality of life，without reducing survival.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
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• The eligibility criteria are: newly diagnosed, untreated, non-distant metastatic, and non-keratinizing NPC; nodes are diagnosed with PET/CT and MRI; staged as T1-4N0-2 or N3 category of non-bilateral lower-neck node metastasis; aged between 18 and 70 years; Karnofsky performance-status score \> 70; adequate haematological function, with a leucocyte count \> 4 × 109/L, haemoglobin \> 90 g/L, and a thrombocyte count \> 100×109/L
Locations
Other Locations
China
Sun Yat-sen University Cancer Center
RECRUITING
Guangzhou
Contact Information
Primary
Ling-Long Tang, Prof
tangll@sysucc.org.cn
02087343840
Time Frame
Start Date: 2024-04-16
Estimated Completion Date: 2031-12-31
Participants
Target number of participants: 470
Treatments
Active_comparator: Standard group
Upper-neck irradiation at the uninvolved neck
Experimental: Experimental group
The low-risk clinical target volume would be reduced to two vertebral levels below the vertebral level of the metastatic level II-V nodes.
Related Therapeutic Areas
Sponsors
Leads: Sun Yat-sen University
Collaborators: Sichuan Cancer Hospital and Research Institute, Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center, Qingyuan People's Hospital, Eye & ENT Hospital of Fudan University, Renmin Hospital of Wuhan University, First People's Hospital of Foshan, First Hospital of China Medical University, First Affiliated Hospital of Guangxi Medical University, Tianjin Medical University Cancer Institute and Hospital, Xiangya Hospital of Central South University