Phase 3 Trial Comparing IMRT or IMPT Plus CIRT for Patients With NPC
The goal of this phase 3 non-inferiority trial is to compare the efficacy and toxicity of proton or photon radiation therapy plus carbon ion radiation therapy for newly diagnosed nasopharyngeal carcinoma. The main question it aims to answer is that if proton radiation therapy plus carbon ion radiation therapy is non-inferior to photon radiation therapy plus carbon ion radiation therapy in terms of therapeutic efficacy. Participants will be randomized to receive either proton radiation therapy (arm 1) or photon radiation therapy (arm 2), in addition to carbon ion radiation therapy (for both arms).
• Willingness to sign the written informed consent.
• Pathologically confirmed Nasopharyngeal carcinoma.
• Patients with any stage of disease except distant metastasis.
• Age: ≥ 18 and ≤ 70 years old.
• Eastern Cooperative Oncology Group score: 0-1.
• Adequate laboratory test results.
• Willingness to accept adequate contraception.