Nasopharyngeal Carcinoma Clinical Trials

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A Randomized, Open-Label, Non-Inferiority Phase III Multicenter Clinical Trial Comparing Reduced-Dose to Standard-Dose Prophylactic Irradiation for Low-Risk Clinical Target Volume (CTV) in the Treatment of Nasopharyngeal Carcinoma.

Status: Recruiting
Location: See all (6) locations...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

To evaluate the locoregional control, survival rate, toxicity, and quality of life in patients with nasopharyngeal carcinoma treated with reduced prophylactic irradiation doses to the Low-Risk Clinical Target Volume (CTV).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:

• Newly diagnosed, untreated, non-distant metastatic, and non-keratinizing NPC; aged between 18 and 70 years; Eastern Cooperative Oncology Group performance score of 0-1; adequate hematologic function (neutrophil count ≥ 1.5 × 10\^9/L, platelet count ≥100×109/L, and hemoglobin≥ 90 g/L); adequate renal function (creatinine ≤ 1.5 upper limit of normal \[ULN\]) or calculated creatinine clearance (CrCl) ≥ 60 mL/min (Cockcroft-Gault formula); and adequate hepatic function (serum bilirubin ≤ 2.0×ULN, and alanine aminotransferase and aspartate aminotransferase ≤ 2.5×ULN).

Locations
Other Locations
China
Dongguan People's Hospital
RECRUITING
Dongguan
Sun yat-sen university cancer center
RECRUITING
Guangzhou
Affiliated Cancer Hospital of Shantou University Medical College
RECRUITING
Shantou
Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center
RECRUITING
Shenzhen
The University of Hong Kong-Shenzhen Hospital
RECRUITING
Shenzhen
Affiliated Hospital of Guangdong Medical University
RECRUITING
Zhanjiang
Contact Information
Primary
Hai-Qiang Mai, Ph. D.
maihq@sysucc.org.cn
+86-020-87343643
Time Frame
Start Date: 2025-11-17
Estimated Completion Date: 2031-11-17
Participants
Target number of participants: 700
Treatments
Experimental: Reduced-dose Radiotherapy for Low-risk CTV
Active_comparator: Standard-dose Radiotherapy for Low-risk CTV
Related Therapeutic Areas
Sponsors
Collaborators: Affiliated Hospital of Guangdong Medical University, Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center, Affiliated Cancer Hospital of Shantou University Medical College, The University of Hong Kong-Shenzhen Hospital, Dongguan People's Hospital
Leads: Sun Yat-sen University

This content was sourced from clinicaltrials.gov

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