Pharmacological (0.05% Atropine) and Non-pharmacological (Defocused Incorporated Multiple Segments Lens) Treatment Effects on the Children With Different Predicted Myopia Progression Rate Measured by Modified Multifocal Electroretinogram

Status: Recruiting
Location: See location...
Intervention Type: Drug, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to compare pharmacological and non-pharmacological treatment effects on the children with different predicted myopia progression rate measured by modified multifocal electroretinogram. The main questions it aims to answer are: * the effectiveness of using 0.05% atropine and prescribing DIMS lens for myopia control in children with different myopia progression rates * the contribution of L/M cones in juvenile myopia progression and changes of retinal activities under atropine and DIMS treatment. Participants will have baseline and follow-up eye examinations and given either pharmacological treatment with 0.05% atropine or non-pharmacological treatment with DIMS lens for myopia control. Researchers will compare the changes of refractive errors and axial length after different types of interventions and investigate the relations between the parameters of mfERG responses and the thicknesses of retinal layers and choroid.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 7
Maximum Age: 9
Healthy Volunteers: t
View:

• be aged between 7 and 9 years

• have no reported eye disorder and no family history of eye disease

• be able to participate in this study for 24 months

• not have any current or history of epilepsy

• not have any current or history of asthma

• have refractive error between 0.50 D and 4.00 D and less than 1.50D of astigmatism with best corrected visual acuity of LogMAR 0.0 or better

• have no detected eye diseases or disorders after eye examination, except myopia

Locations
Other Locations
Hong Kong Special Administrative Region
School of Optometry, Hong Kong Polytechnic University
RECRUITING
Hong Kong
Contact Information
Primary
Henry HL CHAN, PhD
henryhl.chan@polyu.edu.hk
85227667937
Backup
Kaiyip CHOI, PhD
kaiyip.choi@polyu.edu.hk
85234002934
Time Frame
Start Date: 2024-01-01
Estimated Completion Date: 2026-12
Participants
Target number of participants: 80
Treatments
Active_comparator: Atropine 0.05%
Group receiving atropine treatment for 18 months after 6 months of monitoring without intervention
Experimental: DIMS lens
Group receiving DIMS lens treatment for 18 months after 6 months of monitoring without intervention
Related Therapeutic Areas
Sponsors
Collaborators: The University of Hong Kong
Leads: The Hong Kong Polytechnic University

This content was sourced from clinicaltrials.gov

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