• Adult ≥18 years of age

• Have a diagnosis of NF1 based on germline genetic testing or by meeting ≥ 2 the following criteria:

‣ Family history of NF1

⁃ Six or more light brown (cafe-au-lait) spots on the skin

⁃ Presence of two or more neurofibromas of any type, or one or more plexiform neurofibromas

⁃ Freckling under the arms or in the groin area

⁃ Two or more pigmented, benign bumps on the eye's iris (Lisch nodules)

⁃ A distinctive bony lesion: dysplasia (abnormal growth) of the sphenoid bone behind the eye, or dysplasia of long bones, often in the lower leg

⁃ Tumor on the optic nerve that may interfere with vision

• Patients must be seeking treatment for cNF

• Patients must have ≥ 6 paired cNF (3 to be treated and 3 untreated) that are visible and measure between 2-8mm in size. These must be in areas amenable to treatment and surveillance with digital photography.

• cNF must be located on the trunk, arms or legs of the patient

• Able and willing to comply with all visit, treatment and evaluation schedules and requirements

• Able to understand and provide written informed consent