Investigating the Longitudinal Relationships Between Visual Pathway Injury, Radiological and Blood Biomarkers in Multiple Sclerosis and Related Disorders
This study is being conducted to investigate risk factors for disability progression in Multiple Sclerosis and related disorders (MSRD). The primary goal is to assess whether combining information from visual assessment, blood markers, as well as historical and ongoing longitudinal MRIs of the brain, orbit (the part of the skull where eyes are located), and/or spinal cord can predict changes in quantitative disability measures related to MSRD and neurological disease.
• Subjects who meet any one of the following diagnostic criteria:
‣ Diagnosis of MS, CIS,or RIS based on the 2017 revised McDonald criteria.
⁃ Diagnosis of NMOSD based on the 2015 revised NMOSD consensus diagnostic criteria.
⁃ Diagnosis of myelin oligodendrocyte glycoprotein (MOG)-related encephalomyelitis, optic neuritis, or other associated disease.
⁃ Diagnosis of neurological disorders other than MSRD.
⁃ Healthy volunteer.
• Age ≥18.
• Able to give informed consent.