Increased Risk of Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals - Reversibility and Mechanistic Studies.
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The investigators will conduct a proof-of-principle 4-weeks low-calorie diet (LCD) intervention study in low birth weight (LBW) subjects and normal birth weight (NBW) controls with documented (MR scan) liver fat content equal to or above 5%. The investigators will provide extended in-depth mechanistic insight into the role of impaired subcutaneous adipose tissue (SAT) expandability in ectopic fat deposition before and after LCD.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 35
Maximum Age: 40
Healthy Volunteers: f
View:
• subjects with NAFLD (liver fat content ≥5% liver fat content verified on MRS in the screening NAFLD study)
Locations
Other Locations
Denmark
Steno Diabetes Center Aarhus
RECRUITING
Aarhus
Steno Diabetes Center Copenhagen
RECRUITING
Herlev
Contact Information
Primary
Charlotte Brøns, PhD
charlotte.broens.01@regionh.dk
+4526129093
Time Frame
Start Date: 2026-01-01
Estimated Completion Date: 2026-12
Participants
Target number of participants: 8
Treatments
Experimental: individuals with MASLD
individuals with MASLD
Related Therapeutic Areas
Sponsors
Leads: Steno Diabetes Center Copenhagen
Collaborators: Lund University, Aarhus University Hospital