Non Alcoholic Fatty Liver Disease and Endogenous Oxalate Synthesis
Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study aims to determine the daily rate of endogenous synthesis of oxalate using fasted urine collection and a low-oxalate controlled diet in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• age \>18 years
• History of MASLD, with liver fat content \> 5%
• Normal kidney function
• Stable medication for at least 1 month for diabetes mellitus if any
• Willingess to ingest fixed diets and stop dietary supplements for the study and come to UAB for visits
Locations
United States
Alabama
University of Alabama at Birmingham
RECRUITING
Birmingham
Contact Information
Primary
Kyle D Wood, MD
kylewood@uabmc.edu
2059968765
Backup
Sonia Fargue, PhD
sfargue@uabmc.edu
2059756932
Time Frame
Start Date: 2023-04-26
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 28
Treatments
Experimental: Estimation of endogenous oxalate production
Fasted hourly urine collections after equilibration on a low-oxalate diet
Related Therapeutic Areas
Sponsors
Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Leads: University of Alabama at Birmingham