A Multicenter Cross-Sectional Study Evaluating the Diagnostic Accuracy of the Liver Inflammation Index for Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Patients With Concurrent Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Fatty Liver Disease
Status: Recruiting
Location: See all (22) locations...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY
This observational study aims to evaluate a new diagnostic tool, the Liver Inflammation Index, in detecting Metabolic Dysfunction-Associated Steatohepatitis (MASH) among adults who have both Type 2 Diabetes Mellitus (T2DM) and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adults aged ≥18 years, with no restrictions on sex;
• Patients clinically diagnosed with metabolic dysfunction-associated fatty liver disease (MAFLD) according to the Chinese Society of Hepatology guideline Guidelines for the Prevention and Treatment of Metabolic Dysfunction-Associated (Nonalcoholic) Fatty Liver Disease (2024 Edition), and additionally diagnosed with type 2 diabetes mellitus (T2DM) based on the Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes Mellitus (2024 Edition).
Locations
Other Locations
China
Department of Endocrinology, the First Affiliated Hospital of Bengbu Medical University
RECRUITING
Bengbu
Department of Endocrinology, Zhujiang Hospital, Southern Medical University
RECRUITING
Guangzhou
Department of Obesity and Metabolic Diseases, Panyu Hospital of Traditional Chinese Medicine
RECRUITING
Guangzhou
Department of Endocrinology, Hainan General Hospital
RECRUITING
Haikou
Department of Endocrinology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
RECRUITING
Hangzhou
Department of Endocrinology, the Second Affiliated Hospital of Anhui Medical University
RECRUITING
Hefei
Department of Endocrinology, the First Affiliated Hospital of University of South China
RECRUITING
Hengyang
Department of Endocrinology, the Third People's Hospital of Yunnan Province
RECRUITING
Kunming
Department of Endocrinology, Endocrine and Metabolic Disease Medical Center,Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University
RECRUITING
Nanjing
Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University
RECRUITING
Nanning
Department of Endocrinology, the Affiliated Hospital of Qingdao University
RECRUITING
Qingdao
Department of Endocrinology, ZhongShan Hospital, Fudan University
RECRUITING
Shanghai
Department of Endocrinology, the Eighth Affiliated Hospital, Sun Yat-sen University
RECRUITING
Shenzhen
Department of Endocrinology, the First Affiliated Hospital of Soochow University
RECRUITING
Suzhou
Department of Metabolic Diseases and Weight Management, Weifang People's Hospital
RECRUITING
Weifang
Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University
RECRUITING
Wenzhou
Department of Endocrinology, Renmin Hospital of Wuhan University
RECRUITING
Wuhan
Department of Endocrinology, the Second Affiliated Hospital of Wannan Medical University
RECRUITING
Wuhu
Department of Endocrinology and Metabolism, Xijing Hospital, Air Force Medical University
RECRUITING
Xi’an
Department of Endocrinology, Xuzhou Central Hospital
RECRUITING
Xuzhou
Department of Endocrinology, the First Affiliated Hospital of Henan University of CM
RECRUITING
Zhengzhou
Department of Endocrinology, the Affiliated Hospital of Zunyi Medical University
RECRUITING
Zunyi
Contact Information
Primary
Yan Bi, MD,PhD
biyan@nju.edu
86-25-83-105302
Backup
Jin Li, MD,PhD
jinli807@126.com
86-25-83-105302
Time Frame
Start Date: 2026-05-15
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 10000
Treatments
T2DM with MAFLD
Related Therapeutic Areas
Sponsors
Collaborators: The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, The First Affiliated Hospital of Air Force Medicial University, Weifang People's Hospital, First Affiliated Hospital of Wenzhou Medical University, The Second Hospital of Anhui Medical University, Hainan General Hospital, Southern Medical University, China, The First Affiliated Hospital of Bengbu Medical University, The Third People's Hospital of Yunnan Province, Fudan University, The Affiliated Hospital of Qingdao University, Eighth Affiliated Hospital, Sun Yat-sen University, Sir Run Run Shaw Hospital, Panyu Hospital of Traditional Chinese Medicine, The First Affiliated Hospital of University of South China, The First Affiliated Hospital of Soochow University, Xuzhou Central Hospital, Renmin Hospital of Wuhan University, Zunyi Medical College, First Affiliated Hospital of Guangxi Medical University, Second Affiliated Hospital of Wannan Medical College
Leads: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School