A Prospective Clinical Study of Selinexor+Pegaspargase+Dexamethasone in the Treatment of Stage Ⅰ/Ⅱ NK/ T-Cell Lymphoma
evaluate the efficacy and safety of Selinexor+pegaspargase+dexamethasone in early stage NK/ T-cell lymphoma
• Age 18-70 years old, ECOG score 0-2; (including those aged 18 and 70);
• Pre-survival time \> 6 months;
• The pathological tissue was confirmed as NK/T cell lymphoma (the pathological report of the first three months of enrollment could be accepted) (Note: If there is any doubt about the pathological diagnosis, domestic third-party consultation could be organized);
• Clinical stage Ⅰ to Ⅱ (CA stage) with at least one measurable lesion;
• Acceptable hematological indicators, no contraindications to chemotherapy; Neutrophil absolute value ≥1.0×10\^9 /L, platelet ≥75×10\^9 /L, hemoglobin ≥80g/L (except patients with lymphoma bone marrow infiltration);
• Liver function: direct bilirubin ≤1.5× upper limit reference value; Glutamic pyruvic transaminase or glutamic oxalacetic transaminase ≤2.5× upper limit reference value; Alkaline phosphatase ≤3×ULN in non-bone invaded patients;
• Renal function: serum creatinine ≤1.5×ULN;
• Female and male patients of reproductive age and their spouses are willing to use adequate contraception throughout the study period, and female patients of reproductive age must have a negative serum pregnancy test within 7 days before the first dose;
• The newly treated patient had not received other tumor-related treatment in the past;
⁃ Subjects voluntarily participate in the clinical trial, sign informed consent, and cooperate with follow-up;