Non-Small Cell Lung Cancer (NSCLC) Clinical Trials

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A Phase 2, Open-label, Multicohort Study of Rinatabart Sesutecan (Rina-S) in Participants With Non-Small Cell Lung Cancer

Status: Recruiting
Location: See all (74) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

This Phase 2 study will be conducted in different countries around the world with up to about 240 participants. The purpose of this study is to evaluate how well Rina-S works against lung cancer. The treatment in this study is Rina-S monotherapy (by itself). All participants will receive active drug; no one will be given placebo. The treatment duration will be different for every participant, but an average of 12 months is expected. Participants will be asked to attend 1 to 5 visits at the study clinic for each cycle (duration of cycle is 3 weeks). If a participant's cancer stays the same or gets better, and there are not any serious problems, participants can keep getting study treatment for as long as the study is open. Participation in the study will require visits to the study site(s). During site visits, there will be various tests (such as blood draws) and procedures (such as recording of heart activity, imaging/X-rays) to monitor whether the study treatment is safe and effective.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Participant has histologically or cytologically confirmed metastatic or locally advanced NSCLC of adenocarcinoma histology, not amenable to curative surgery or radiotherapy.

• Participant must have radiological disease progression while on or after receiving the most recent regimen.

• Participants either may have actionable genetic alterations (AGAs) or no AGAs.

• Participant has measurable disease according to RECIST v1.1.

• Participant has an Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) score of 0 or 1 within 7 days of Cycle 1 Day 1.

Locations
United States
California
Compassionate Cancer Care Center
RECRUITING
Fountain Valley
Kaiser Permanente San Diego Mission Road
RECRUITING
San Diego
Providence Medical Foundation (St. Joseph Heritage Healthcare)
RECRUITING
Santa Rosa
Washington, D.c.
MedStar Georgetown University Hospital
RECRUITING
Washington D.c.
Florida
Moffitt Cancer Center and Research Institute
RECRUITING
Tampa
Georgia
Emory Winship Cancer Institute
RECRUITING
Atlanta
Montana
St. Vincent Frontier Cancer Center
RECRUITING
Billings
North Carolina
UNC Health - University of North Carolina
RECRUITING
Chapel Hill
Nebraska
Nebraska Hematology-Oncology
RECRUITING
Lincoln
New Jersey
Astera Cancer Care
RECRUITING
East Brunswick
New York
ONE Onc: New York Oncology Hematology
RECRUITING
Albany
Montefiore Medical Park
RECRUITING
The Bronx
Oregon
Williamette Valley Cancer Institute and Research Center
RECRUITING
Eugene
Providence Portland Medical Center
RECRUITING
Portland
Providence Oncology & Hematology Care Clinic - Westside
RECRUITING
West Haven-sylvan
Tennessee
Tennessee Oncology - Nashville St. Thomas Midtown Clinic
RECRUITING
Nashville
Tennessee Oncology Nashville - SCRI Oncology Partners
RECRUITING
Nashville
Texas
Baylor Charles A. Sammons Cancer Center
RECRUITING
Dallas
Virginia
Virginia Cancer Specialists
RECRUITING
Fairfax
Other Locations
Australia
St Andrews Medical Centre
RECRUITING
Adelaide
Chris O'Brien Lifehouse
RECRUITING
Camperdown
Icon Cancer Centre Hobart
RECRUITING
Hobart
Icon Cancer Care - Townsville
RECRUITING
Hyde Park
St John of God Murdoch Hospital
RECRUITING
Murdoch
GenesisCare North Shore
RECRUITING
Saint Leonards
Belgium
Chu Helora Hospital La Louvière Site Jolimont
RECRUITING
La Louvière
UZ Leuven - Gasthuisberg Campus
RECRUITING
Leuven
AZ Delta (Campus Wilgenstraat)
RECRUITING
Roeselare
China
Beijing Chest Tumor Hospital
RECRUITING
Beijing
Shanghai East Hospital
RECRUITING
Shanghai
Tianjin Medical University Cancer Institute and Hospital
RECRUITING
Tianjin
The First Affiliated Hospital of Hebei North University
RECRUITING
Zhangjiakou
Henan Cancer Hospital
RECRUITING
Zhengzhou
France
Assistance Publique Hôpitaux de Marseille - Hôpital Nord
RECRUITING
Marseille
Cochin Hospital
RECRUITING
Paris
Groupe Hospitalier Paris Saint-Joseph
RECRUITING
Paris
Institut Curie - Centre de Recherche
RECRUITING
Paris
Lyon Sud Hospital Center
RECRUITING
Pierre-bénite
Germany
Evangelische Lungenklinik Berlin
RECRUITING
Berlin
Universitaetsklinikum Essen
RECRUITING
Essen
Krankenhaus Martha-Maria Halle-Dölau
RECRUITING
Halle
Hungary
Bács-Kiskun Megyei Kórház - Kecskemét
RECRUITING
Kecskemét
Szent Borbála Hospital
RECRUITING
Tatabánya
Italy
Istituto di Candiolo - IRCCS
RECRUITING
Candiolo
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)
RECRUITING
Meldola
Japan
Kyoto Prefectural University of Medicine
RECRUITING
Kyoto
Japan Community Health Care Organization Chukyo Hospital
RECRUITING
Nagoya
Kitasato University Hospital
RECRUITING
Sagamihara
Saitama Medical University International Medical Center
RECRUITING
Saitama
NHO Kinki Chuo Chest Medical Center
RECRUITING
Sakai
Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital
RECRUITING
Tokyo
Kanagawa Cardiovascular and Respiratory Center
RECRUITING
Yokohama
Netherlands
The Netherlands Cancer Institute (NKI)
RECRUITING
Amsterdam
Leids Universitair Medisch Centrum
RECRUITING
Leiden
Poland
Gdański Uniwersytet Medyczny
RECRUITING
Gdansk
KOMED Roman Karaszewski I Wspolnicy Spolka Jawna
RECRUITING
Krakow
Instytut MSF
RECRUITING
Lodz
MedPolonia
RECRUITING
Poznan
Spain
Hospital Germans Trias i Pujol
RECRUITING
Barcelona
Parc de Salut Mar - Hospital del Mar
RECRUITING
Barcelona
USP Instituto Universitario Dexeus
RECRUITING
Barcelona
START Rioja
RECRUITING
Logroño
Clinica Universidad de Navarra - Madrid
RECRUITING
Madrid
Hospital Universitario 12 de Octubre
RECRUITING
Madrid
MD Anderson Cancer Center Madrid
RECRUITING
Madrid
Hospital Quirón Málaga
RECRUITING
Málaga
Clinica Universidad de Navarra - Pamplona
RECRUITING
Pamplona
Fundación IVO. Instituto Valenciano de Oncología
RECRUITING
Valencia
Hospital Clinico Universitario de Valencia
RECRUITING
Valencia
Taiwan
Changhua Christian Hospital
RECRUITING
Changhua
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING
Kaohsiung City
Taipei Medical University - Shuang Ho Hospital, Ministry of Health and Welfare
RECRUITING
New Taipei City
Chi Mei Medical Center - Liouying
RECRUITING
Tainan
National Cheng Kung University
RECRUITING
Tainan
Contact Information
Primary
Genmab Trial Information
clinicaltrials@genmab.com
+4570202728
Time Frame
Start Date: 2026-01-30
Estimated Completion Date: 2028-11-22
Participants
Target number of participants: 240
Treatments
Experimental: Rina-S
Multiple cohorts (Cohorts A, B, C, D, and E) will receive Rina-S as monotherapy.
Sponsors
Leads: Genmab

This content was sourced from clinicaltrials.gov

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