Non-Small Cell Lung Cancer (NSCLC) Clinical Trials

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A Randomized, Double-blinded, Multiregional Phase 3 Study of Ivonescimab Versus Pembrolizumab for the First-line Treatment of Metastatic Non-small Cell Lung Cancer in Patients Whose Tumors Demonstrate High PD-L1 Expression

Status: Recruiting
Location: See all (202) locations...
Intervention Type: Biological
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

Clinical study of ivonescimab for first-line treatment of metastatic NSCLC patients with high PD-L1. Evaluating overall survival and progression free survival.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age ≥ 18 years old at the time of enrollment

• Eastern Cooperative Oncology Group (ECOG) performance status score of 0 - 1

• Expected life expectancy ≥ 3 months

• Metastatic (Stage IV) NSCLC

• Histologically or cytologically confirmed squamous or non-squamous NSCLC

• Tumor demonstrates high PD-L1 expression ( TPS\>50%) based on a 22C3 immunohistochemistry ( IHC) clinical assay approved / cleared by local health authorities.

• At least one measurable noncerebral lesion according to RECIST 1.1

• No prior systemic treatment for metastatic NSCLC.

Locations
United States
Arkansas
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Hot Springs
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Chandler
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Phoenix
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Cerritos
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Glendale
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Irvine
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Los Angeles
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Mountain View
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Murrieta
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Newport Beach
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Roseville
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Sacramento
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San Diego
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San Francisco
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Santa Ana
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Whittier
Colorado
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Aurora
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Grand Junction
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Greeley
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Lone Tree
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Loveland
Florida
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Fort Lauderdale
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Hialeah
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Jacksonville
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Miami
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North Venice
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Orlando
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Pensacola
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Plantation
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Plantation
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Tallahassee
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Tamarac
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West Palm Beach
Georgia
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Atlanta
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Macon
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Macon
Iowa
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Waukee
Illinois
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Carterville
Indiana
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Indianapolis
Kentucky
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Lexington
Louisiana
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Covington
Massachusetts
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Boston
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Milton
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Worcester
Maryland
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Baltimore
Michigan
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Detroit
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Detroit
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Lansing
Minnesota
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Minneapolis
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Saint Louis Park
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Saint Paul
Missouri
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Kansas City
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St Louis
Mississippi
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Hattiesburg
North Carolina
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Chapel Hill
New Hampshire
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Lebanon
New Jersey
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Basking Ridge
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Middletown
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Montvale
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Mullica Hill
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New Brunswick
New York
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Glen Falls
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Harrison
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New York
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Syracuse
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Uniondale
Ohio
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Columbus
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Lebanon
Oklahoma
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Oklahoma City
Oregon
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Eugene
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Portland
Pennsylvania
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Philadelphia
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Pittsburgh
Tennessee
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Nashville
Texas
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Abilene
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Austin
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Dallas
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Forth Worth
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Houston
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Tyler
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Webster
Utah
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Salt Lake City
Virginia
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Blacksburg
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Charlottesville
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Fairfax
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Richmond
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Richmond
Washington
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Seattle
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Vancouver
Other Locations
Canada
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Edmonton
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London
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Montreal
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Montreal
China
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Changchun
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Changzhou
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Fuzhou
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Ganzhou
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Guangzhou
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Guangzhou
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Haikou
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Hangzhou
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Harbin
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Kunming
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Nanchang
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Shanghai
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Tai’an
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Taizhou
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Weifang
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Wenzhou
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Xi'an
France
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Brest
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Créteil
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Lyon
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Marseille
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Nantes
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Paris
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Rennes
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Villejuif
Germany
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Chemnitz
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Gauting
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Giesen
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Karlsruhe
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Minden
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Moers
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Möser
Greece
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Athens
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Rio
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Thessaloniki
Hungary
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Budapest
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Kecskemét
Italy
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Bari
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Milan
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Milan
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Orbassano
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Parma
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Roma
Japan
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Asahikawa
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Bunkyō-ku
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Hidaka
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Hirakata
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Kanazawa
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Koto-ku
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Kumamoto
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Kurume
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Matsusaka
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Nagoya
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Nishinomiya
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Okayama
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Omura-shi
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Osaka
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Sakai
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Sendai
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Shimotsuke
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Tokyo
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Wakayama
Mexico
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Guadalajara
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Mexico City
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Monterrey
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Veracruz
Poland
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Gdansk
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Lodz
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Lublin
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Poznan
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Skorzewo
Portugal
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Braga
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Coimbra
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Faro
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Porto
Romania
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Baia Mare
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Bucharest
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Cluj-napoca
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Cluj-napoca
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Craiova
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Iași
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Ovidiu
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Suceagu
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Timișoara
Serbia
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Belgrade
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Belgrade
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Kragujevac
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Novi Sad
Spain
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Badajoz
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Badalona
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Barcelona
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Girona
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Las Palmas
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Lugo
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Madrid
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Málaga
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Seville
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Valencia
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Zaragoza
Turkey
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Adana
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Ankara
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Antalya
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Diyarbakır
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Gaziantep
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Istanbul
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Istanbul
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İzmit
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Konya
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Seyhan
Contact Information
Primary
Summit Clinical Trial Information
medicalinformation@smmttx.com
1-833-256-0522
Time Frame
Start Date: 2025-02-27
Estimated Completion Date: 2029-06
Participants
Target number of participants: 780
Treatments
Experimental: Arm A - Ivonescimab
Subject will receive ivonescimab as an IV injection
Active_comparator: Arm B - Pembrolizumab
Subject will receive pembrolizumab as an IV injection
Sponsors
Leads: Summit Therapeutics

This content was sourced from clinicaltrials.gov