Effect of Trazodone on Obstructive Sleep Apnea Endotypes and Severity

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1/Phase 2
SUMMARY

Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. Some OSA patients with low arousal threshold wake up prematurely during an obstructive event and do not have time for spontaneous upper airway (UA) dilator muscle recruitment. As a consequence they are exposed to apnea and hypopnea cycling. In this protocol the investigators will test the effect of trazodone administered before sleep on OSA traits and OSA severity during sleep.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Maximum Age: 70
Healthy Volunteers: f
View:

• Moderate-to-severe OSA (AHI ≥ 15 events/hr)

Locations
United States
Massachusetts
Brigham and Women's Hospital
RECRUITING
Boston
Contact Information
Primary
Ludovico Messineo
lmessineo@bwh.harvard.edu
(617) 732-4013
Time Frame
Start Date: 2024-01-01
Estimated Completion Date: 2026-06-01
Participants
Target number of participants: 18
Treatments
Placebo_comparator: Placebo
Placebo capsule 30 min before sleep
Experimental: Trazodone
Trazodone capsule 30 min before sleep
Related Therapeutic Areas
Sponsors
Leads: Brigham and Women's Hospital

This content was sourced from clinicaltrials.gov