Impact of Sleep Disorders on Innate Immunity in COVID-19 Patients. A Cohort Study
Status: Recruiting
Location: See location...
Intervention Type: Biological
Study Type: Observational
SUMMARY
Sleep is an important modulator of the immune response, whereby sleep disturbances (ie, poor sleep quality, insufficient sleep and/or primary sleep disorder, obstructive sleep apnea (OSA)) contribute to inflammatory disease risk and dysregulation of immune response in front of infectious agents. The objective of this study is to evaluate the impact of undiagnosed and non-treated sleep disorders on innate immunity in a cohort of COVID-19 patients and the role of trained immunity induced by influenza vaccination in the innate immune response.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: t
View:
• Participants over 18 years old with diagnosis of COVID-19 during first year of coronavirus pandemic in March-June 2021.
Locations
Other Locations
Spain
Hospital Universitari Parc Tauli
RECRUITING
Sabadell
Contact Information
Primary
Andrea F Grau, Medicine
andreagrau94@gmail.com
+34608151458
Time Frame
Start Date: 2023-11-06
Estimated Completion Date: 2024-09-30
Participants
Target number of participants: 50
Treatments
Participants who have had severe COVID-19 infection with sleep disturbance
This cohort of participants will be recruited from participants in ongoing study in our institution (CEIm 2021/5096) where exploring contributions of sleep disorders on severity of COVID-19.~To explore present sleep status participants will be asked to fill out sleep questionnaires referred to their sleep characteristics since COVID-19 episode until present moment. As objective evaluation of sleep participants will perform a night home sleep study with WatchPAT® 300 sleep recording, Itamar Medical Ltd.~Cohort 1 will be those participants who have had a severe COVID19 infection and have been diagnosed with a sleep disorder.
Participants who have had severe COVID-19 infection without sleep disorder
Participants with severe COVID19 infection and no currently diagnosed sleep disorders
Participants who have had mild COVID-19 infection with sleep disturbance
Participants who have had a mild COVID19 infection and have been diagnosed with a sleep disorder
Participants who have had mild COVID-19 infection without sleep disorder
Participants who have had a mild COVID19 infection and have not been diagnosed with a sleep disorder
Related Therapeutic Areas
Sponsors
Leads: Parc Taulí Hospital Universitari