Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
A pilot N-of-1 randomized controlled trial evaluating the effectiveness of a personalized CPAP intervention in reducing atrial fibrillation (AF) burden and improving AF-related quality of life in patients with moderate to severe obstructive sleep apnea (OSA).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: f
View:
• Informed consent
• Age 18-85 years
• High burden paroxysmal AF (≥1%)
• Moderate-severe OSA (AHI ≥ 15)
• Implanted device with atrial diagnostics
• Enrolled in remote monitoring
Locations
United States
Ohio
Cleveland Clinic
RECRUITING
Cleveland
Washington
University of Washington
NOT_YET_RECRUITING
Seattle
Contact Information
Primary
Mina Chung, MD
CHUNGM@ccf.org
2164442290
Backup
Reena Mehra, MD
mehrar@medicine.washingon.edu
216-272-7405
Time Frame
Start Date: 2025-08-25
Estimated Completion Date: 2026-05-31
Participants
Target number of participants: 20
Treatments
Experimental: Alternating CPAP vs. No Treatment
Each participant undergoes alternating 2-week periods of CPAP treatment and no treatment over approximately 13 weeks. This personalized intervention evaluates changes in AF burden and quality of life, with patients serving as their own controls.
Related Therapeutic Areas
Sponsors
Collaborators: University of Washington
Leads: The Cleveland Clinic