MicroRNAs as Biomarkers for Obstructive Sleep Apnea
Status: Recruiting
Location: See all (3) locations...
Intervention Type: Device
Study Type: Observational
SUMMARY
Although obstructive sleep apnea (OSA) is a common disorder, there are no blood biomarkers for identification and management of these patients. This project will study microRNAs in order to develop and validate blood biomarkers that are specific to OSA, useful for identification of cases with OSA, reflective of efficacy of therapy, and able to predict blood pressure response to treatment of OSA.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
View:
• age 18-75 years
• moderate-severe OSA (defined as AHI ≥15 events/hour)
• willing to accept PAP therapy
• age 18-75 years
• no OSA (defined as AHI \<5 events/hour)
Locations
United States
Ohio
The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600
RECRUITING
Columbus
Pennsylvania
University of Pennsylvania
RECRUITING
Philadelphia
Other Locations
Iceland
University of Iceland
RECRUITING
Reykjavik
Contact Information
Primary
Colleen M Walsh, MS
walshco@pennmedicine.upenn.edu
215-614-0047
Backup
Kristie C Nguyen
kristie.nguyen@pennmedicine.upenn.edu
215-615-4112
Time Frame
Start Date: 2024-04-01
Estimated Completion Date: 2028-04-30
Participants
Target number of participants: 500
Treatments
Cases
Moderate-severe OSA (defined as AHI ≥15 events/hour)
Controls
No OSA (defined as AHI \<5 events/hour)
Related Therapeutic Areas
Sponsors
Leads: University of Pennsylvania
Collaborators: National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI)