Pharmacological Activation of Hypoglossal Motor Nucleus for Obstructive Sleep Apnea Aim 2
Who is this study for? Patients with obstructive sleep apnea
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1/Phase 2
SUMMARY
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon leads to increased collapsibility of UA compared to normal subjects. In this protocol the investigators will test the effect of LTM1201AZ, LTM1201AT, LTM1201AD, LTM1201AG administered before sleep on OSA phenotype traits and OSA severity during sleep.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:
• AHI \> 10 events/h during NREM supine sleep
Locations
United States
Massachusetts
Brigham and Women's Hospital
RECRUITING
Boston
Time Frame
Start Date: 2019-03-01
Estimated Completion Date: 2022-12-31
Participants
Target number of participants: 16
Treatments
Placebo_comparator: Placebo
Placebo capsule before bedtime
Experimental: LTM1201AZ
LTM1201AZ capsule before bedtime
Experimental: LTM1201AT
LTM1201AT capsule before bedtime
Experimental: LTM1201AG
LTM1201AG capsule before bedtime
Experimental: LTM1201AD
LTM1201AD capsule before bedtime
Related Therapeutic Areas
Sponsors
Leads: Brigham and Women's Hospital