Prevalence of Obstructive Sleep Apnoea Among Adolescents in the General Population

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Obstructive sleep apnoea (OSA) is associated with a variety of important complications, namely cardiovascular, neurocognitive and metabolic disturbances. The prevalence of OSA is well studied in children and adults. However, adolescence - an interface between childhood and adulthood, and a period of developmental changes known to affect sleep is largely unexplored in relation to OSA. The only published prevalence study on adolescents is limited by its small sample size, not a true representation of the general population and primarily focused on Caucasians. In this proposal, the investigators aim to determine the prevalence of OSA, and associated clinical features in a population-based sample of adolescents aged between 12 and 16 years. The sample selection will be based on a stratified (by districts) and clustered (subjects within randomly selected schools) randomised sampling frame. Each participant will fill in a sleep habit questionnaire, undergo anthropometric measurements, physical examination and complete home polysomnographic recordings. Participants will undergo Conners' Continuous Performance Test and have blood samples taken to phenotype their cardiovascular and metabolic risk. The primary outcome is prevalence of OSA, assessed by the obstructive apnoea hypopnoea index. Secondary outcomes include use of logistic regression models to assess association between different severities of OSA and various demographic, clinical and laboratory variables. The obtained result will provide the much-needed OSA prevalence in adolescents which is essential for estimating the true burden of disease within this population. This information is also vital when considering population-based health policies and interventional strategies. Globally, the findings from currently evidence-sparse region of the world allow future international comparison of disease burden. Our study will also form a platform from which repeated measurements can be made to assess time trends and to answer the important question of whether adulthood OSA takes its origin from adolescence.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 12
Maximum Age: 16
Healthy Volunteers: t
View:

• Adolescents aged 12-16 years

• Written informed consent from parents and assent from participants available

Locations
Other Locations
Hong Kong Special Administrative Region
Department of Paediatrics, The Chinese University of Hong Kong
RECRUITING
Shatin
Contact Information
Primary
Chun T Au
junau@cuhk.edu.hk
+85235052917
Time Frame
Start Date: 2019-12-13
Estimated Completion Date: 2024-12
Participants
Target number of participants: 740
Related Therapeutic Areas
Sponsors
Leads: Chinese University of Hong Kong

This content was sourced from clinicaltrials.gov