Longitudinal Observational Study Using Functional and Structural Optical Coherence Tomography to Diagnose and Guide Treatment of Glaucoma
The specific aims of the clinical studies are to: * Develop a directional high-resolution OCT and OCT angiography prototype to improve imaging of structure and perfusion. * Validate wide-field OCT and OCT angiography parameters to improve early glaucoma detection. * Simulate visual field results by combining structural and angiography OCT data. * Assess abilities of above technologies and OCT-derived parameters on predicting glaucoma detection, conversion, and progression.
• No history or evidence of retinal pathology or glaucoma
• Normal Humphrey 24-2 VF: A mean defect (MD), corrected pattern standard deviation (CPSD) within 95% limits of normal reference, and glaucoma hemifield test (GHT) within normal limits (97%).
• Intraocular pressure \< 21 mm Hg
• Central corneal pachymetry \> 500 microns
• No chronic ocular or systemic corticosteroid use
• Open angle (gonioscopy must show 75% or more of the angle to be Grade 2 or more by Shaffer's grading system)
• Normal appearing ONH and NFL: vertical and horizontal cup/disc ratio (CDR) ≤ 0.5 and intact neuroretinal rim without peripapillary hemorrhages, notches, localized pallor, or NFL defect
• Symmetric ONH between left and right eyes: CDR difference \< 0.2 in both vertical and horizontal dimensions
• ONH or NFL defect visible on slit-lamp biomicroscopy defined as one of following:
‣ diffuse or localized thinning of the rim
⁃ disc (splinter) hemorrhage
⁃ notch in the rim
⁃ vertical cup/disc ratio greater than the fellow eye by \> 0.2
• Presence or absence of VF defects as measured by Humphrey SITA 24-2 VF.