A Mechanistic Investigation of Risk Factors for Opioid Use Disorder: Examining Hippocampal-based Context-dependent Learning and Memory Associated With Adverse Childhood Experiences
The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults. The study will compare measures of learning and memory across three groups of participants: those with an Opioid Use Disorder (OUD) that take buprenorphine for opioid replacement therapy, adults without an Opioid Use Disorder taking buprenorphine, and healthy adults that do not have an Opioid Use Disorder and are not taking buprenorphine.
• Right handed
• Able to give informed consent
• Normal/corrected-to-normal vision and hearing
• Diagnosis of OUD
• Be actively receiving buprenorphine (BUP) for opioid agonist therapy
• Be free from illicit substance use for at least 2 weeks
• The study will allow stable dose (\> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol)
• Taking BUP for chronic pain
• No Substance Use Disorder (including OUD)
• The study will allow stable dose (\> 3 months) of commonly prescribed psychiatric medications and some sleep aids (per protocol)
• Not taking BUP
• Free of any psychiatric or major medical conditions