Neurofeedback to Reduce Anhedonia and Improve Outcomes in Opioid Use Disorder: a Feasibility Study
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This feasibility study collects initial data on the use of an fMRI neurofeedback protocol for treating anhedonia in methadone-treated individuals with opioid use disorder (OUD). The intervention tested has previously been shown to reduce anhedonia in individuals with depression and this study is collecting first-in-human data in an OUD population. Investigators will assess tolerability of the intervention and collect preliminary data from 2-3 subjects monitoring changes in anhedonia, non-substance-related autobiographical memory recall, and meaning in life.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: f
View:
• ≥3 months of methadone treatment for OUD
• Presence of anhedonia, as assessed via SHAPS
• Baseline autobiographical memory deficit, as assessed via AMT
Locations
United States
Connecticut
APT Foundation
RECRUITING
New Haven
Contact Information
Primary
Sarah Paprotna
sarah.paprotna@yale.edu
+1 (203) 737-5994
Time Frame
Start Date: 2026-08
Estimated Completion Date: 2027-02
Participants
Target number of participants: 3
Treatments
Experimental: Individuals with OUD
Participants will complete five study visits. They will receive neurofeedback at two separate scanning sessions (sessions 2-3). Neurofeedback scans will include rest, neurofeedback, and transfer (i.e., no feedback) runs, one week apart.
Related Therapeutic Areas
Sponsors
Leads: Yale University