ISO-101 a Novel Device for the Treatment of Orthostatic Hypotension - a Signal of Efficacy Study
The goal of this clinical trial is to test a novel medical device (ISO-101) in patients diagnosied with orthostatic hypotension. The main question\[s\] it aims to answer are: * to determine whether the ISO-101 device demonstrates a signal of efficacy in people with OH and whether it is worthy of further clinical evaluation. * Assess the safety and performance of the ISO-101 device in patients with orthostatic hypotension. Participants will use the device under controlled conditions and have the following parameters measured before and after standing up: * blood pressure * markers of peripheal vascular resistence * sympathetic nervous system activity measure before and after standing up
• Willing and able to give informed consent for participation in the study
• Adults aged over 18 years with a clinical diagnosis of orthostatic hypotension
• A drop in systolic BP of ≥20 mmHg (with or without a drop in diastolic BP ≥10 mmHg) within 3 minutes of standing up from a supine position
• Able to stand up from a supine position (with assistance if required)