∙ Subjects meeting the following inclusion criteria are to be included in the analysis:

• Patients receiving CERAMENT G subsequent to surgical excision of osteomyelitis, with Cierny-Mader classification grades III or IV, who require dead-space management of a bone defect following surgical debridement and excision of infection.

• Symptoms for a minimum of six months with clinical and radiological features accompanied by at least one of the following:

‣ the presence of a sinus

⁃ the presence of an abscess or intra-operative pus

⁃ the presence of positive supportive histology

⁃ two or more microbiological cultures with indistinguishable organisms (defined as cultures resulting in identification of the same microbe (e.g., Staph aureus) with similar antimicrobial sensitivity) Notes: In cases where cultures are negative, a patient will be included in the study only if there is positive supportive histology combined with the presence of a draining sinus or intra-operative pus. Infected non-unions will be included only if the bone loss is \< 1cm after debridement and excision of bone has been performed.