Oral Beta-lactams Versus Non-beta-lactamS for Treatment of Lower Extremity Osteomyelitis
The goal of this clinical trial is to compare different classes of oral antibiotics (beta-lactam and non-beta-lactam antibiotics) for the treatment of bone infections of the leg and foot. The hypothesis is that oral beta-lactam antibiotics work as well as oral non-beta-lactam antibiotics to treat these infections. The first step is to assess whether it is possible to perform the trial by determining whether participants can be recruited and followed successfully. If the trial is proven to be possible, it will be expanded to ensure an answer to whether the two antibiotic classes work as well for the treatment of bone infections of the leg and foot.
• Adult (\> 18 years old)
• OM of the lower extremity (below the knee) as determined by the treating healthcare provider (clinically and/or radiographically)
• Expected duration of treatment at least 28 additional days of antibiotic therapy for the infection episode, from the time of enrolment
• Treating health care team has already transitioned or is willing to transition to oral antibiotic therapy for the remainder of the treatment duration