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Anabolic Versus Catabolic Skeletal Effects of Endurance or Resistance Exercise in Older Veterans

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences blood markers of bone resorption for either endurance or resistance exercise. The purpose of this study is to determine 1) if resistance exercise causes a similar increase in bone resorption as endurance exercise; and 2) if exercise training influences the increase in bone resorption following exercise for both endurance and resistance exercise.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Healthy Volunteers: t
View:

• Healthy older (60+ y) Veteran women and men in the Denver Metro Area

• Normally active (e.g., recreational cycling or walking exercise)

Locations
United States
Colorado
Rocky Mountain Regional VA Medical Center, Aurora, CO
RECRUITING
Aurora
Contact Information
Primary
Sarah J Wherry, PhD
sarah.wherry@va.gov
(720) 848-6475
Backup
Toby Wellington, MS
toby.wellington@va.gov
(720) 848-6376
Time Frame
Start Date: 2022-07-06
Estimated Completion Date: 2027-03-31
Participants
Target number of participants: 120
Treatments
Experimental: Resistance Exercise
Participants will perform total body resistance training 3x per week for 10 weeks. Each exercise session will last approximately 1 hour.
Experimental: Endurance Exercise
Participants will complete 60 minutes of stationary cycling 3x per week at 70-80% of maximal heart rate for 10 weeks.
Related Therapeutic Areas
Sponsors
Leads: VA Office of Research and Development
Collaborators: University of Colorado, Denver

This content was sourced from clinicaltrials.gov