''Comparative Evaluation of Change in Bite Force and Levels of Bone Turnover Markers CTX and BALP in Hyperdivergent and Hypodivergent Cases During Retention Phases-A Prospective Clinical Trial ''

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Long-term studies have shown that various occlusal changes occur after the active phase of orthodontic treatment. some of these changes are unwanted changes and are considered as relapse The retention appliances are used to maintain the arch dimensions and alignment of the teeth after completion of the orthodontic treatment. One indicator of the functional state and health of the masticatory system is maximum voluntary bite force (MVBF). Its values vary in accordance to the location of measurement (highest at the first molar, lower at the incisors). People with pronounced horizontal craniofacial growth have somewhat higher values of MVBF, and those with vertical growth have lower values than do those with an average growth pattern. Clinical case reports and descriptive histologic data exist suggesting that bone and tooth remodeling persist for extended periods after removal of appliance or deactivation. A reflection of bone remodelling can be found in the gingival crevicular fluid (GCF) of moving teeth, with decrease or increase in the concentration of biomarker. This prompted us to evaluate the expression of variation in bone turnover marker levels (CTX-Bone resorption marker and BALP -Bone formation marker ) during the retention period. The International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry (IFCC) have recommended C-terminal telopeptide of type I collagen (CTX) as one of the reference for BTMs. Hence, The present trial will be undertaken to assess the changes and compare if there is any difference in bite force and change in level of bone biomarker biomarker CTX type 1 collagen(C-terminal telopeptide of type I collagen and bone specific alkaline phosphatase(BALP) in post orthodontic treatment hypodivergent and hyperdivergent cases using beggs retainer over 12 months of period of retention.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: t
View:

• Non - growing (18-25) patients who had finished Fixed orthodontic cases ( ready for debonding )with FMA of 26 or more for hyperdivergent cases and FMA of 24 or less for hypodivergent cases

• Optimal functional occlusion at end of treatment (PAR score \>70%).

• Littles irregularity index (Pre-treatment \<6mm in both upper and lower arch).

• Nonsurgical and non-orthopedic patients and non syndromic patients.

• Optimal periodontal condition and Good oral hygiene (probing depth \<3mm, gingival index score \<1

• Good compliance regarding retainer wear

Locations
Other Locations
India
Dr Rekha
RECRUITING
Rohtak
Contact Information
Primary
Dr manisha kukreja, MDS
mk3pgids@gmail.com
9215650617
Backup
Dr Aaliya khan
draaliyakha@gmail.com
9711549786
Time Frame
Start Date: 2024-12-25
Estimated Completion Date: 2026-08
Participants
Target number of participants: 40
Treatments
Other: vertical grower
Patients belonging to group 1 will be patient with vertical growth pattern who have undergone fixed orthodontic cases and are ready for debonding with FMA of 26 0 or more. Begg's Retainer will be formed by conventional method and delivered within 24 hours of debonding. Changes in levels of bone turnover markers CTX-bone resorption and BALP-bone formation using ELISA and compare the bite force
Other: Horizontal grower
Patients belonging to group 2 will be patient with horizontal growth pattern who have undergone Fixed orthodontic cases and are ready for debonding with with FMA Of 24 o or less.Changes in levels of bone turnover markers CTX-bone resorption and BALP-bone formation using ELISA and compare the bite force
Related Therapeutic Areas
Sponsors
Leads: Postgraduate Institute of Dental Sciences Rohtak

This content was sourced from clinicaltrials.gov