Modulation of the Gut Microbiome by Dietary Fiber to Improve Calcium Absorption and Bone Health in Older Men

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

Osteoporotic fractures are a major but underrecognized problem in men. There is growing evidence that low dietary fiber intake is a modifiable risk factor for age-related bone loss in men. Preclinical and human studies in adolescents and postmenopausal women suggest that dietary fiber intake influences bone metabolism by modulating the gut microbiome to augment intestinal calcium absorption, but it is unclear through what molecular mechanism and whether dietary fiber has the same effects in older men. In this crossover intervention study, the investigators will enroll and follow 30 older male Veterans to evaluate the effects of soluble corn fiber on intestinal calcium absorption and explore the contribution of the gut microbiome.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 60
Healthy Volunteers: t
View:

• Male Veterans 60 years of age

Locations
United States
California
San Francisco VA Medical Center, San Francisco, CA
RECRUITING
San Francisco
Contact Information
Primary
Karin C Wu, MD
karin.Wu@va.gov
(415) 221-4810
Time Frame
Start Date: 2025-01-01
Estimated Completion Date: 2029-01-01
Participants
Target number of participants: 30
Treatments
Experimental: Group 1
Soluble corn fiber 20g/day x 4 weeks, washout period for 4 weeks, and placebo (maltodextrin) x 4 weeks.
Experimental: Group 2
Placebo (maltodextrin) 20g/day x 4 weeks, washout period for 4 weeks, and soluble corn fiber x 4 weeks.
Related Therapeutic Areas
Sponsors
Leads: VA Office of Research and Development
Collaborators: San Francisco VA Health Care System

This content was sourced from clinicaltrials.gov