• This study will enroll women with platinum resistant high grade serous ovarian cancer.

• This study is open to minorities as appropriate but is not designed to measure differences in intervention effects.

• All patients must be registered for screening prior to study enrollment, however, if biomarker testing results are not required prior to enrollment to a substudy, then enrollment can proceed immediately. CCTG will advise sites when biomarker testing results are required prior to substudy enrollment.

• Additional Criteria To Be Met Prior To Sub-study Enrollment All patients must fulfill all of the following criteria to be eligible for enrollment to the study. Additional eligibility criteria and relevant timings that are specific to a substudy are listed in each substudy specific protocol.

• Patients must have platinum resistant high grade serous carcinoma of ovarian, fallopian tube or peritoneal origin defined as progression within 6 months of last platinum containing chemotherapy. Histological confirmation of the original primary tumour is required.

• All patients must have measurable disease as defined by RECIST 1.1. The criteria for defining measurable disease are as follows:

‣ Chest x-ray ≥ 20 mm

⁃ CT scan (with slice thickness of 5 mm) ≥ 10 mm - longest diameter

⁃ Physical exam (using calipers) ≥ 10 mm

⁃ Lymph nodes by CT scan ≥ 15 mm - measured in short axis

• Patients must have at least one disease site amendable to pre and on-treatment biopsies and must consent to undergo these tumour biopsies.

• Prior surgery is permitted provided that a minimum of at least 28 days have elapsed between any major surgical procedure and date of enrollment, and that wound healing has occurred.

• Systemic Therapy:

‣ There is no limit to the number of prior regimens for platinum-sensitive disease. However, patients may not have received more than one cytotoxic chemotherapy regimen for platinum-resistant disease.

⁃ Patients may have received non-cytotoxic therapies (excluding agents targeted by the planned substudy). Refer to each substudy protocol for exclusions.

⁃ Prior treatment with an immune checkpoint inhibitor (ICI) is permissible providing the ICI was not discontinued for severe or recurrent severe toxicity (including myocarditis, or other myocardiotoxicity, encephalitis, colitis, diarrhea, pancreatitis, hypo/hyper thyroidism, hypopituitarism, adrenal insufficiency, rash, autonomic neuropathy, myasthenia gravis, Guillain-Barre, myositis/polymyositis, hepatitis, nephritis, Type 1 diabetes, thrombocytopenia)

⁃ A minimum of 4 weeks must have elapsed between last dose of prior therapy and enrollment.

⁃ All reversible prior toxicity must have recovered to grade ≤ 1 (consult CCTG in the case of irreversible toxicity)

• Other Therapy:

• • Radiation, endocrine therapy, or other non-anti-cancer investigational agents are permitted provided a minimum of 28 days (4 weeks) have elapsed between the last dose and enrollment. Exceptions may be made for low-dose, non-myelosuppressive radiotherapy after consultation with CCTG.

• ECOG performance status 0 or 1 and have a life expectancy ≥ 3 months.

• Patients must be ≥ 18 years of age.

• All patients must have consented to:

∙ Release of tumour block from their primary or metastatic tumour, if available. If archival tissue is unavailable, a tumour biopsy is required during screening. The centre/pathologist must have agreed to the submission of the specimen(s).

‣ Pre and on treatment tumour biopsies:

• Core needle (a minimum of 6 core samples are required) or excisional biopsies or resected tissue specimens are required.

• CCTG will advise sites when biomarker testing results are required prior to enrollment

• Patients must be willing and able to comply with scheduled visits, treatment schedule, laboratory testing, and other requirements of the trial.

• Patients must have adequate organ and marrow function measured within 7 days prior to enrollment including;

• Absolute neutrophils ≥ 1.5 x 10\^9/L (1500/µL)

• Platelets ≥ 100 x 10\^9/L (100 x 103/µL)

• Hemoglobin ≥90g/L\* (10.0 g/dL) with no blood transfusions in the past 28 days.

• Bilirubin ≤ 1.5 x ULN (upper limit of normal)\*\*

• AST \& ALT ≤ 2.5 x ULN; if patient has liver metastases ≤ 5.0 x ULN

• Serum creatinine or: Creatinine clearance ≤ 1.5 x ULN / \>50 mL/min

• Albumin \>35 g/L (3.5 g/dL)

• INR/PTT INR \< 1.7 or PTT \< 4 seconds above control

• Patient consent must be appropriately obtained in accordance with applicable local and regulatory requirements. Each patient must sign a consent form prior to enrollment in the trial to document their willingness to participate.

• Patients must be accessible for treatment and follow up. Patients enrolled on this trial must be treated and followed at the participating centre. This implies there must be reasonable geographical limits (for example: 1 ½ hour's driving distance) placed on patients being considered for this trial.

• Patient must agree to return to their primary care facility for any adverse events, response assessments and follow-up, which may occur through the course of the trial.

• In accordance with CCTG policy, protocol treatment is to begin within 2 working days of patient enrollment.

• Women of childbearing potential will have a pregnancy test to determine eligibility as part of the Pre-Study Evaluation