A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of APG-2449 Monotherapy or in Combination With Anticancer Agents in Patients With Platinum-resistant Recurrent Ovarian Cancer or Advanced Solid Tumors
An open, multicenter, dose-exploring Phase I trial include Part A and Part B to evaluate the safety, tolerability and efficacy of APG-2449.
• Part A: No gender limitation. Patients with histologically and/or cytologically confirmed ALK/ROS1 gene fusion positive non-small cell lung cancer and various advanced tumors.
• Part B: Female only. Histologically proven ovarian epithelial, fallopian tube, or primary peritoneal carcinoma.
• At least one measurable tumor lesion.
• ECOG score is 0\
• Life expectancy of ≥3 months.
• AE caused by previous treatment must recover to ≤ grade 1.
• Sufficient bone marrow, liver, kidney and coagulation function.
• Female patients must be in a non-pregnant and non-lactating state.
• Able to understand and willing to sign informed consent.
• Patients are required to provide fresh or archived tumor tissue samples prior to treatment.