Ovarian Cancer Clinical Trials

⁃ Part A and B:

• Have histologically confirmed high-grade serous or high-grade endometrioid ovarian, primary peritoneal, or fallopian tube cancer.

• Have confirmed availability of tumor tissue block or slides

• Have radiographic progression on or after most recent line of systemic anticancer therapy

• Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.

• Have measurable disease per RECIST v1.1

⁃ Part A:

• Have platinum-resistant disease, defined as radiographic progression less than or equal to (≤)6 months of the last administration of platinum therapy.

• Have previously received greater than or equal to (≥)1 but ≤3 prior lines of systemic cytotoxic therapy. Up to 4 lines of prior therapy is allowed if one of those lines is mirvetuximab soravtansine.

• Have received prior bevacizumab treatment, unless documented contraindication or intolerance.

• Have received treatment with a poly(ADP-ribose) polymerase inhibitor (PARPi) if known to have a somatic or germline breast cancer gene (BRCA) mutation, if clinically indicated, unless documented contraindication or intolerance.

⁃ Part B:

• Have relapsed after first-line platinum-based chemotherapy and have platinum-sensitive disease defined as radiographic progression greater than (\>)6 months of their last administration of platinum therapy

• Have previously received ≥1 but ≤2 prior lines of systemic cytotoxic chemotherapy

• Have previously received a PARPi, per local product label, with progression on, or within 6 months of completion of PARPi treatment.