• Histologically confirmed diagnosis of PDAC

• Pancreatic cancer tumor, lymph node, metastasis (TNM) pathological staging values of T1-T3, N0-N2, and M0 per the American Joint Committee on Cancer (AJCC) Cancer Staging Manual

• Macroscopically complete (R0 or R1) resection of PDAC

• Unequivocal absence of disease after surgery as assessed by the investigator within 28 days prior to treatment initiation

• CA19-9 level measured within 14 days prior to initiation of study treatment

• Interval of between 6 and 12 weeks since resection of PDAC

• Full recovery from surgery and ability to receive atezolizumab, autogene cevumeran, and mFOLFIRINOX in the investigator's judgment

• Adequate hematologic and end-organ function

• Female participants of childbearing potential must be willing to avoid pregnancy during the treatment period and for 28 days after the final dose of autogene cevumeran, for 9 months after the last dose of chemotherapy, and for 5 months after the final dose of atezolizumab. They must refrain from donating eggs for 9 months after the last dose of chemotherapy.

• Male participants with a female partner of childbearing potential or pregnant female partner must remain abstinent or use specified contraceptive methods during the treatment period and for 28 days after the final dose of autogene cevumeran and for 6 months after the last dose of chemotherapy. Men must refrain from donating sperm during this same period.