Effect and Mechanism of Deep Brain Stimulation and Transcranial Magnetic Stimulation on Parkinson's Disease With Cognitive Impairment
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Observational
SUMMARY
This study intends to apply structural and functional brain network neuroimaging techniques combined with image post-processing methods to explore the differences in brain network changes in PD patients with cognitive impairment after DBS or TMS.
Eligibility
Participation Requirements
Sex: All
Maximum Age: 75
Healthy Volunteers: f
View:
• 1\. The clinical diagnosis of PD is consistent with the United Kingdom Parkinson's Disease Society Brain Bank criteria, with disease duration over 5 years, acute levodopa motor response ≥30%, and indication for STN-DBS.
Locations
Other Locations
China
Tianjin Huanhu Hospital
RECRUITING
Tianjin
Contact Information
Primary
Zhao Guangrui, doctor
Guangrui-Zhao@hotmail.com
+86 18956405513
Backup
Feng Keke, doctor
fengke1976@163.com
+86 18920195507
Time Frame
Start Date: 2023-11-01
Estimated Completion Date: 2027-11-01
Participants
Target number of participants: 200
Treatments
Cognitive Impairment (CI) group and No Cognitive Impairment (NCI) group
We intend to recruit 200 patients with primary PD to undergo DBS surgery or only TMS treatment according to whether the surgical indication is available. We will observe the changes in cognitive function of patients before and after different brain stimulation treatments.~Parkinson's disease patients with cognitive impairment after brain stimulation were divided into cognitive impairment group, and those without cognitive impairment after treatment were divided into no cognitive impairment group
Related Therapeutic Areas
Sponsors
Leads: Tianjin Huanhu Hospital