Cortical Electrophysiology of Response Inhibition in Parkinson's Disease
Patients with Parkinson's Disease will be studied before, during, and after a deep brain stimulation implantation procedure to see if the stimulation location and the size of the electrical field produced by subthalamic nucleus (STN) DBS determine the degree to which DBS engages circuits that involve prefrontal cortex executive functions, and therefore have a direct impact on the patient's ability to inhibit actions.
• diagnosis of idiopathic Parkinson's disease (PD)
• Hoehn and Yahr (H\&Y) stage 2-4 (off medication)
• diagnosis of idiopathic PD
• there is a clinical indication for DBS surgery
• normal preoperative MRI
• ability to tolerate microelectrode-guided neurosurgery in an awake state
• diagnosis of idiopathic PD
• functioning DBS system
• age 45-75