Clinical Investigation of the Relationship Between Disease Severity and Periodontal Status in Patients With Pemphigus Vulgaris

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

The aim of this study is to evaluate the relationship between the severity of Pemphigus Vulgaris (a chronic autoimmune skin disease) and periodontal (gum) health. Researchers will assess disease activity using the Oral Disease Severity Score (ODSS) for mouth lesions and measure serum Desmoglein 1 and 3 levels through blood tests. These findings will be compared with clinical gum measurements, such as pocket depth and attachment levels. The study intends to determine how the clinical and biochemical severity of Pemphigus Vulgaris impacts periodontal tissues and overall oral health.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients aged 18 years and older.

• Clinically and histopathologically confirmed diagnosis of Pemphigus Vulgaris.

• Presence of at least 10 natural teeth.

• Willingness to participate and signed informed consent.

Locations
Other Locations
Turkey
University of Health Sciences, Gulhane Faculty of Dentistry, Department of Periodontology
RECRUITING
Ankara
Contact Information
Primary
Bilkan KARA, Dr.
bilkankara@gmail.com
+905383781679
Time Frame
Start Date: 2025-11-01
Estimated Completion Date: 2026-02-21
Participants
Target number of participants: 20
Treatments
Pemphigus Vulgaris Group
A comprehensive oral examination including ODSS scoring and periodontal measurements (PPD, CAL, PI, GI). Additionally, serum Desmoglein 1 and 3 levels will be retrieved from the patients' medical records for biochemical correlation.
Sponsors
Leads: Saglik Bilimleri Universitesi

This content was sourced from clinicaltrials.gov