• Squamous cell carcinoma confirmed by histology or cytology;

• Clinical Stage is Locally advanced penile cancer (T4, any N stage; or any T stage, N3);

• No prior chemotherapy for newly diagnosed or relapsed patients or the time from the last chemotherapy to relapse should be longer than 12 months;

• There is at least one measurable lesion according to the solid tumor efficacy evaluation standard RECIST1.1;

• the Eastern Cooperative Oncology Group (ECOG) scored 0-2;

• Blood marrow function: Hemoglobin(Hb) \>/= 80g/L; White blood cell count \>/= 3.0x10\^9/L; Neutrophil count \>/= 1.5x10\^9/L; Platelet count \>/ = 100x10\^9/L;

• Liver function: AST, ALT, ALP \</= 2.5 ULN; Total bilirubin \</= 1.5 ULN;

• Estimated survival \>/= 12 months;

• No prior serious disease history of a systemic organ;

⁃ The participant understands this study procedure and signs the informed consent.