A Single-Center, Evaluator-blind, Randomized Control Study to Assess the Effectiveness and Safety of Collagen Membrane (FormaAid®) in the Treatment of Periodontal Regeneration
The goal of this clinical trial is to evaluate clinically and radiographically effectiveness and products safety of the collagen membrane (FormaAid®) in the treatment of periodontal regeneration using guided tissue regeneration (GTR) performed by the trained periodontists. The main question it aims to answer are: * The difference of periodontal status: clinical attachment level (CAL), periodontal pocket depth (PPD), gingival recession (GR), gingival Index (GI) and plaque index (PI). * The difference of intrabony defect height. * The difference of gingival tissue thickness and gingival tissue volume. * The incidences of safety indicators. Participants will be randomized into either experiment group or control group, undergo guided tissue regeneration (GTR) surgery at week 1, and re-visited on week 3, 5, 13 and 27 after the GTR surgery. Researchers will compare if the test product is non-inferior to Bio-Gide.
• Age between 18 70 years old, male or female
• Non current smoker: A person who has not smoked more than 100 cigarettes from the past to the present and has not smoked in the last 30 days.
• Patients who have decided to pay at their own expense and require guided tissue regeneration (GTR) for periodontal regeneration
• The defect morphology of intrabony defects is 2 or 3 wall intrabony defect.
• Periodontal pocket depth ≥ 5mm (probing periodontal depth, PPD, distance from gingival margin to the bottom of the defect).
• The height of the bone defect in the X ray image is ≥ 3mm (according to the X ray film intraosseous defect)
• The diagnosis of periodontal disease is stage III with either grade B or C.
• Patients who are willing to adhere to the study protocol and sign the informed consent form.
• Willing to accept evaluation during the trial period and return to clinic and treatment.
• Not a person subject to a sentence of guardianship or subject to judicial guardians.