Evaluation of Subgingival Mechanical Periodontal Therapy with the Additional Local Application of a Spermidine-Based Gel
Status: Recruiting
Location: See location...
Intervention Type: Procedure, Other
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
This study investigates the effectiveness of using a spermidine-based gel as an adjunct to minimally invasive non-surgical periodontal therapy (MINST) for treating periodontitis. The primary outcome is to assess whether the addition of spermidine gel reduces pocket depth (PPD) compared to MINST alone. Secondary outcome include evaluating other periodontal parameters like bleeding on probing, FMBS and FMPS and CAL over a 12-month period.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:
• Age 18 years or older. Presence of untreated periodontitis with at least 2 sites showing clinical attachment loss (CAL) \> 2 mm and probing depth (PD) \> 4 mm.
• Voluntary signing of informed consent.
Locations
Other Locations
Italy
AOU Federico II
RECRUITING
Naples
Contact Information
Primary
Luca Ramaglia, Professor
luca.ramaglia@unina.it
081-7462496
Time Frame
Start Date: 2025-01-25
Estimated Completion Date: 2026-01-20
Participants
Target number of participants: 12
Treatments
Experimental: MINST plus spermidine gel
Active_comparator: MINST (minimally invasive non surgical tecnique)
Related Therapeutic Areas
Sponsors
Leads: Luca Ramaglia