Assessment of Pro-Resolution Mediator Levels in Periodontitis Stage III and IV Before and After Periodontal Therapy
This study aims to assess Pro-Resolution Mediator levels during non-surgical periodontal therapy in individuals with Stage III and IV periodontitis, comparing them to healthy subjects. Periodontitis, a chronic inflammatory condition affecting tooth-supporting tissues, can lead to tooth loss and systemic complications. Understanding the role of pro-resolving lipid mediators in inflammation resolution may offer insights into therapeutic benefits associated with these mediators.
• Adult patients above 18 years old.
• Interdental CAL at site of greatest loss ≥5 mm or extending to middle third of the root.
• Interdental CAL at site of greatest loss ≥8 mm or extending to apical third of the root.
• Probing depth ≥6 mm.
• Vertical bone loss ≥3 mm.
• Tooth loss due to periodontitis of ≤4 teeth. (Periodontitis Stage III)
• Tooth loss due to periodontitis of ≥5 teeth. (Periodontitis Stage IV)
• Furcation involvement Class II or III Moderate ridge defect.
• \-
• Systemically healthy patients.
• Patients with an age range between 16 to 80 years.
• Patients have a minimum of 20 teeth.
• Less than 10% bleeding sites with probing depths ≤3 mm.
• absence of erythema, oedema.