Assessment of Treatment Outcomes and Alveolar Bone Changes Following Intentional Replantation of Hopeless Periodontally Involved Single-Rooted Teeth - A Pre-test, Post-test Interventional Study

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This research aims to evaluate the effectiveness of intentional replantation (IR) as a treatment for single-rooted teeth diagnosed as hopeless due to true periodontic lesions. The study will assess changes in alveolar bone and periodontal tissues, symptom resolution, and patient-reported outcomes (satisfaction and quality of life) following the procedure. Cone beam computed tomography (CBCT) imaging will be used to track radiographic changes at baseline and 9 months, while clinical examinations will monitor symptom resolution, including pain, swelling, and tooth mobility. The study is a single-arm pre-test, post-test interventional design conducted at the College of Dentistry, University of Science and Technology Fujairah (new name: University of Fujairah). Participants will include adults aged 18-70 with single-rooted teeth deemed hopeless due to periodontic lesions. Participants will undergo intentional replantation, and data will be collected through clinical examinations, radiographic images, and patient questionnaires at baseline and 9 months. Statistical analysis will compare pre- and post-treatment outcomes using paired-samples t-tests or Wilcoxon signed-rank tests, depending on data normality. The study aims to provide a comprehensive evaluation of intentional replantation, contributing valuable insights into its clinical effectiveness for managing complex dental conditions.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: t
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⁃ Patients meeting the specified criteria will be included in the study.

• The patients with American Society of Anesthesiologists physical status classification 1 and 2.

• Radiographic bone loss of at least 50% around the targeted tooth.

• Probing depth of at least 5 millimetres around the targeted tooth.

• Grade III mobility (extreme mobility) of the targeted tooth according to Miller's classification.

• Grade II mobility or less (minimal to slight increased mobility without functional impairment) of adjacent teeth.

• Distance between the targeted tooth and adjacent teeth less than 2 millimetres.

• Patient preference for tooth retention through intentional replantation over extraction.

Locations
Other Locations
United Arab Emirates
Dental Clinic, College of Dentistry, University of Fujairah,
RECRUITING
Al Fujairah City
Contact Information
Primary
Nabeel Ayappali Kalluvalappil, MDS
nabeelsabeel@gmail.com
+971504614791
Backup
Tamer Hamed Hassan, PhD
t.hassan@uof.ac.ae
+971902023500
Time Frame
Start Date: 2025-03-25
Estimated Completion Date: 2026-08-15
Participants
Target number of participants: 45
Treatments
Experimental: Intentional Replantation of Hopeless Periodontally Involved Single-Rooted Teeth
This study evaluates the outcomes of intentional replantation of hopeless periodontally involved single-rooted teeth using a pre-test, post-test interventional design.~At baseline, clinical and CBCT assessments will be performed to evaluate alveolar bone levels, periodontal status, and tooth mobility. The intervention involves atraumatic extraction, extraoral conditioning (if needed), and replantation with stabilization.~At 9 months, follow-up CBCT and clinical evaluations will assess bone changes, periodontal healing, and tooth stability.
Related Therapeutic Areas
Sponsors
Leads: University of Fujairah

This content was sourced from clinicaltrials.gov