Effect of Photodynamic Therapy as an Adjunct to Non-Surgical Treatment of Periodontitis

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Photodynamic therapy (PDT) is an innovative technique that utilizes light-activated agents, known as photosensitizers, to produce reactive oxygen species capable of targeting and eliminating pathogens. This therapeutic approach has been explored in a variety of medical fields due to its versatility and minimal invasiveness. In the context of periodontal diseases, PDT has emerged as a promising adjunctive treatment in the non-surgical management of periodontitis. Periodontitis, a chronic inflammatory disease caused by the accumulation of pathogenic bacteria in the subgingival environment, is often treated with mechanical debridement, including scaling and root planing (SRP). However, these conventional methods may not always achieve complete bacterial eradication. PDT, when used in conjunction with SRP, has the potential to significantly enhance bacterial elimination. The use of photosensitizers, activated by specific wavelengths of light, leads to the generation of singlet oxygen, which can effectively kill a broad spectrum of periodontal pathogens, including those resistant to antibiotics. As an adjunctive therapy, PDT can improve the clinical outcomes of non-surgical periodontitis treatment by reducing bacterial load, promoting tissue healing, and potentially decreasing the need for more invasive procedures. The ability of PDT to target bacteria without harming surrounding tissues makes it an attractive option for patients who require a non-invasive treatment approach. In conclusion, photodynamic therapy is a valuable addition to periodontal treatment regimens, offering enhanced bacterial reduction and improved therapeutic outcomes in the management of periodontitis.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients aged 18 years or older with periodontitis diagnosed according to EFP/APA 2018 criteria and with at least 10 teeth in the mouth.

Locations
Other Locations
Portugal
Egas Moniz School of Health and Science
ACTIVE_NOT_RECRUITING
Almada
Egas Moniz School of Health and Science
RECRUITING
Almada
Contact Information
Primary
Filipa Sousa, Master
filipampsousa@gmail.com
00351 915028912
Backup
Inês Dra. Gomes, phd
inesgomes.ciiem@egasmoniz.edu.pt
00351 212 946 748
Time Frame
Start Date: 2025-04-08
Estimated Completion Date: 2025-11-30
Participants
Target number of participants: 20
Treatments
Active_comparator: Non-surgical periodontal treatment
Conventional non-surgical treatment - scaling and root planing
Experimental: Antimicrobial photodynamic therapy
Scaling and root planing + aPDT (antimicrobial photodynamic therapy)
Related Therapeutic Areas
Sponsors
Leads: Egas Moniz - Cooperativa de Ensino Superior, CRL

This content was sourced from clinicaltrials.gov